Neuro-Cytotoxic profile of Poly Vinyl Pirrolidone (PVP) Iron Oxide nanoparcicle, an in vitro assessment on SH-SY5Y cell line

Description: Magnetic Iron Oxide nanoparticles as magnetite ones (Fe3O NP), due to their physic-chemical and superparamagnetic properties, are widely used in various industrial applications such as: audio speaker devices, position sensors, water purification (heavy metal elimination); and medical such as: drug and gene delivery, imaging, contrast agent. Although, several studies suggest that Fe43ONP may arrive to central nervous system (CNS) independently of the route of administration (i.e.inhalatory, intravenous or intra peritoneal), and there is a lack of data about molecular interaction of these NPs with cerebral cells. Actually, scientific evidence indicates that the presence of iron ions, iron oxides and iron oxide nanoparticles into nervous system tissues are linked to several neurodegenerative diseases (i.e.Alzheimer; Parkinson). 4

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