Study on inflammation-related genes and microRNAs, with special emphasis on the vascular repair factor HGF and miR-574-3p, in monocytes and serum of patients with T2D
- Authors
- Drexhage, Hemmo Arjan
- Format
- Article
- Status
- publishedVersion
- Description
Recently, we reported signs of inflammation (raised IL-8, reduced miR-146a) and signs of vascular repair (raised HGF) in the serum of Ecuadorian patients with type 2 diabetes (T2D). In contrast, we found that the circulating monocytes lacked up-regulation of classical inflammatory genes (IL-1B, IL-6, and TNF) and there was even significant down-regulation of PTGS2. Notably, genes and a microRNA involved in adhesion, cell differentiation and morphology (CD9, DHRS3, PTPN7 and miR-34c-5p) were up-regulated in the T2D monocytes, suggesting a role of the anti-inflammatory cells in adhesion, vascular repair and invasion.
https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-015-0113-5
- Publication Year
- 2016
- Language
- eng
- Topic
- TYPE 2
DIABETES
MONOCYTES
SERUM
- Repository
- Repositorio SENESCYT
- Rights
- openAccess
- License
- openAccess