Preliminary study of prevalence of high risk genotypes of human papilloma virus (HPV) in a community located in the northern coast of Ecuador

Description: Human Papilloma Virus (HPV) infection is the most common viral sexually transmitted disease worldwide. Although HPV infection has been associated to majority of cervical cancer cases in Ecuador, there is no information about prevalence and infecting genotypes. The aim of this study was to determine the prevalence of HPV high risk genotypes in a community located in the northern coast of Ecuador, and its correlation with age, Pap smear results, and number of sexual partners. Samples (n = 63) were taken from a rural community in the northern coast of Ecuador during April and July 2006.
The human papilloma virus is a member of the papovaviridea family. It is a small virus, with only 55nm in diameter. The virus genome is a single molecule of double – stranded, circular DNA. The DNA can be divided into three main regions, a noncoding region which contains promoter, enhancer and silencer sequences that regulate DNA replication. The second region contains protein coding sequences of E2, E4, E5, E6 and E7. The third region encodes L1 and L2, both are structural proteins for the viral capside. (3) Once the virus enters the host cell it begins replication. Cell cycle abnormalities and cancer are the result strongly associated to the transcription of genes E6 and E7 (1, 3)

Topic: Virus del papiloma humano
Cuello uterino - Cáncer - Análisis de casos
Virus del papiloma humano - Análisis de casos - Costa Nororiental - Ecuador
Medicina
CIENCIAS
MICROBIOLOGÍA